植物细胞亲环素研究进展

白宇杰1,2, 马华升2, 王火旭1, 阮松林2,*
1 辽宁师范大学生命科学学院, 辽宁大连116029; 2 杭州市农业科学研究院生物技术研究所植物分子生物学与蛋白质组学实验室, 杭州310024

通信作者:阮松林;E-mail: ruansl1@hotmail.com;Tel: 0571-87093826

摘 要:

亲环素(cyclophilin, CyP)是能够与免疫抑制药物环孢霉素 A (cyclosporine A, CsA)特异结合的、高度保守的一个蛋白 家族, 广泛存在于细菌、酵母、植物和动物等各种有机体中。在高等植物中存在多种同工型亲环素, 它们位于细胞浆、细 胞核、线粒体和叶绿体等不同亚细胞分室中, 参与多种重要的生理生化过程。本文从亲环素的发现、结构特点、生化特性 及生物学功能等方面进行综述, 并对植物亲环素研究前景进行了讨论。

关键词:亲环素; 肽脯氨酰顺反异构酶; 环孢霉素A; 免疫抑制

收稿:2010-05-19   修定:2010-06-17

资助:国家转基因重大专项(2009ZX08001-027B)、浙江省自然科学基金(Y307016)和杭州市重大科技创新项目(200723 12A0 3) 。

Advances in Plant Cyclophilins

BAI Yu-Jie1,2, MA Hua-Sheng2, WANG Huo-Xu1, RUAN Song-Lin2,*
1College of Life Sciences, Liaoning Normal University, Liaoning 116029, China; 2Plant Molecular Biology and Proteomics Laboratory, Institute of Biotechnology, Hangzhou Academy of Agricultural Sciences, Hangzhou 310024, China

Corresponding author: RUAN Song-Lin; E-mail: ruansl1@hotmail.com; Tel: 0571-87093826

Abstract:

Cyclophilin is a highly conserved protein family that can specifically bind to the immunosuppressive drug cyclosporin A, which has been found in diverse organisms including bacteria, yeast, plants, and animals. In higher plants, there exist multiple isoforms that are located in different sub-cellular compartments including cytoplasm, nucleus, mitochondria, chloroplast, and are involved in numerous physiological and biochemical processes. Here, the discovery, structure, biochemical characteristics and biological function on plant cyclophilins are reviewed, and prospects of plant cyclophilins are discussed.

Key words: cyclophilin; peptidyl-prolyl cis-trans-isomerase; cyclosporin A; immunosuppressant

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