植物JAZ蛋白家族研究进展

魏昕1,2,3,刘雨恒1,2,3,刘宇阳1,2,3,殷晓浦1,2,3,谢恬1,2,3,谌容1,2,3,卫秋慧1,2,3,*
1杭州师范大学医学部药学院, 杭州311100;2浙江省榄香烯类抗癌中药研究重点实验室, 杭州311100;3浙产中药材资源开发与应用浙江省工程实验室, 杭州311100

通信作者:卫秋慧;E-mail: wqh_268@163.com

摘 要:

JAZ (Jasmonate ZIM-domain)蛋白是植物中一种重要的负调控因子, 最初从模式植物拟南芥(Arabidopsis thaliana)中分离鉴定。 JAZ蛋白结构包含ZIMJasNT三个保守结构域。 JAZ蛋白可通过与植物中转录因子或其他蛋白相互作用参与植物生长发育过程中多种生理过程的调控。本文将介绍JAZ蛋白的结构特征, 以及响应茉莉酸(JA)及其他信号通路的转导途径, 并详细综述JAZ蛋白与不同蛋白相互作用参与植物多种生理过程的研究进展, 并进一步展望JAZ蛋白在药用植物中可能的调控作用, 以期为培育活性成分高积累的药用植物新品种提供分子基础和理论依据。

关键词: JAZ蛋白; JA途径; 转录因子; 互作

收稿:2020-11-18   修定:2021-03-05

资助:国家自然科学基金(81903742)和浙江省自然科学基金 (LQ19C020002)

Advances of JAZ family in plants

WEI Xin1,2,3, LIU Yuheng1,2,3, LIU Yuyang1,2,3, YIN Xiaopu1,2,3, XIE Tian1,2,3, CHEN Rong1,2,3, WEI Qiuhui1,2,3,*
1College of Pharmacy, School of Medicine, Hangzhou Normal University, Hangzhou 311100, China; 2Key Laboratory of Elemene Class Anti-cancer Chinese Medicine of Zhejiang Province, Hangzhou 311100, China; 3Engineering Laboratory of Development and Application of Traditional Chinese Medicine from Zhejiang Province, Hangzhou 311100, China

Corresponding author: WEI Qiuhui; E-mail: wqh_268@163.com

Abstract:

JAZ is an important negative regulator in plants, which was originally identifed and isolated from
the model plant
Arabidopsis thaliana. The structure of JAZ contains three conserved domains: ZIM, Jas and NT. JAZs can participate in the regulation of various physiological processes during plant growth and development by interacting with transcription factors or other proteins in plants. This article introduces the structural characteristics of JAZ proteins as well as the signal response pathway to jasmonic acid (JA). Then, the research progress of JAZs involved in various physiological processes of plants is reviewed in detail. We further look forward to the possible regulator role of JAZs in secondary metabolism of medicinal plants. All these will lay a foundation for breeding new medicinal plant varieties with high accumulation of active ingredients.

Key words: JAZ protein; JA pathway; transcription factor; interaction

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