磷脂酸磷酸酶在脂质代谢和信号转导中的作用及其调控

李一路, 张晴晴, 胡卫芹, 屈钢, 洪月云*
华中农业大学作物遗传改良国家重点实验室, 武汉430070

通信作者:洪月云;E-mail: hongyy@mail.hzau.edu.cn

摘 要:

磷脂酸磷酸酶(phosphatidic acid phosphatase, PAP)催化磷脂酸(phosphatidic acid, PA)而产生二脂酰甘油(diacylglycerol, DAG)。PA和DAG均是脂代谢的关键中间产物, 也是信号分子。因此, PAP在脂质代谢和信号转导过程中具有重要作用。本文回顾了近期有关PAP的研究进展, 概述了PAP的结构特征、生化特性和时空调控, 阐述了PAP在脂质代谢中的作用及其生理效应和分子调控, 并提出有关PAP尚未清楚的问题及今后的研究方向。

关键词:磷脂酸磷酸酶; 磷脂酸; 二脂酰甘油; 脂质代谢与信号

收稿:2017-03-15   修定:2017-04-14

资助:国家自然科学基金(31271514)。

Roles and regulation of phosphatidic acid phosphatase in lipid metabolism and signaling

LI Yi-Lu, ZHANG Qing-Qing, HU Wei-Qin, QU Gang, HONG Yue-Yun*
National Key Laboratory of Crop Genetic Improvement, Huazhong Agricultural University, Wuhan 430070, China

Corresponding author: HONG Yue-Yun; E-mail: hongyy@mail.hzau.edu.cn

Abstract:

Phosphatidic acid phosphatase (PAP) catalyzes phosphatidic acid (PA) to produce diacylglycerol (DAG). Both PA and DAG are important lipid intermediates and signal molecules involved in lipid metabolism and signaling transduction. Here, we summarized recent research defining the structure, biochemical properties, tissue distribution, subcellular localization, and biological functions of PAP in plants. The molecular mechanism in lipid metabolism and the future perspective were also described in this review.

Key words: phosphatidic acid phosphatase; phosphatidic acid; diacylglycerol; lipid metabolism and signaling

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