植物类Caspase及其调控细胞程序性死亡的研究进展

詹洁1,2, 何虎翼1,3, 李文1, 何龙飞1,*
广西大学1农学院, 2国防教育学院, 南宁530005; 3 广西农业科学院经济作物研究所, 南宁530007

通信作者:何龙飞;E-mail: lfhe@gxu.edu.cn;Tel: 0771-3235212-801

摘 要:

植物细胞程序性死亡(PCD)在植物生长发育和逆境适应中发挥重要作用。半胱氨酸蛋白酶(caspase)调控动物PCD的 启动、执行及信号转导。通过人工合成底物、动物caspase抑制剂等方法已证实在植物中存在类caspase, 可分为metacas- pases、VPEs (vacuolar processing enzymes)和saspases等。本文综述了植物类caspase的种类、结构、定位、功能及其调控 PCD的研究进展, 提出植物PCD中类caspase作用的调控途径, 为深入研究植物PCD提供参考。

关键词:植物; 细胞程序性死亡; 类半胱氨酸蛋白酶; 调控途径

资助:国家自然科学基金(30960181)和广西大学科研基金(XJZ-100341)。

Progress in Caspase-Like Proteases and Their Regulatory Roles in Programmed Cell Death in Plants

ZHAN Jie1,2, HE Hu-Yi1,3, LI Wen1, HE Long-Fei1,*
1College of Agronomy, 2College of National Defense Education, Guangxi University, Nanning 530005, China; 3Cash Crops Research Institute, Guangxi Academy of Agricultural Sciences, Nanning 530007, China

Corresponding author: HE Long-Fei; E-mail: lfhe@gxu.edu.cn; Tel: 0771-3235212-801

Abstract:

Programmed cell death (PCD) plays an important role in the development and adaptation of plants under different environmental stresses. Cysteine-aspartic acid proteases (caspase) are responsible for initiating, executing and signal transduction of animal PCD. The existence of caspase-like proteases has been also demonstrated experimentally in plants by the applications of artificial synthesized substrates and inhibitors of caspase. Caspase-like proteases can be divided into three classes including metacaspases, vacuolar processing enzymes (VPEs) and saspases. In the paper, the progresses of the types, structures, locations, functions of caspase-like proteases and their regulatory roles in plant PCD are reviewed. Subsequently, a regulatory pathway of caspaselike proteases in plant PCD is also suggested. It can support a new insight into further study of caspase-like proteases and their effects in plant PCD.

Key words: plant; PCD; caspase-like proteases; regulatory pathway

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