植物螯合肽的转运与功能研究进展

张中春, 邱保胜*
华中师范大学生命科学学院, 湖北省遗传调控与整合生物学重点实验室, 武汉430079

通信作者:邱保胜;E-mail: bsqiu@mail.ccnu.edu.cn;Tel: 027-67862470

摘 要:

植物螯合肽(phytochelatins, PCs)是由植物螯合肽合酶催化谷胱甘肽合成的一类生物小分子, 结构式为(γ-Glu-Cys)n- Gly (n=2~11), 在真菌和高等植物耐受重金属胁迫机制中具有重要作用。近年来, 人们在PC介导重金属脱毒害的分子机理 研究上取得了重要进展, 发现SpHMT1和SpABC2是PC在裂殖酵母中介导重金属液泡区室化的主要转运蛋白, 鉴定了拟南 芥液泡膜PC转运蛋白AtABCC1和AtABCC2。此外, PCs也可能在超积累植物细胞内对重金属脱毒害具有重要功能。

关键词:超积累植物; 植物螯合肽; 重金属; 转运蛋白

收稿:2011-12-14   修定:2012-03-22

资助:教育部新世纪优秀人才计划项目(NCET-08-0786)

Research Advances of Phytochelatin Transport and Its Function

ZHANG Zhong-Chun, QIU Bao-Sheng*
Hubei Key Laboratory of Genetic Regulation and Integrative Biology, College of Life Sciences, Central China Normal University,Wuhan 430079, China

Corresponding author: QIU Bao-Sheng; E-mail: bsqiu@mail.ccnu.edu.cn; Tel: 027-67862470

Abstract:

Phytochelatins (PCs) are synthesized by PC synthases from glutathione with the general structure of (γ-Glu-Cys)n-Gly (n=2-11). They are necessary for heavy metal tolerance in fungi and higher plants. Recent studies have shown that both SpHMT1 and SpABC2 play an important role in PC-mediating heavy metal sequestration in the vacuole of Schizosaccharomyces pombe, while AtABCC1 and AtABCC2 are the major transporters for removing PC-heavy metal complexes from cytosol into the vacuole of Arabidopsis thaliana. In addition, several studies have suggested that PCs might detoxify heavy metal inside the cells of hyperaccumulator.

Key words: hyperaccumulator; phytochelatin; heavy metal; transporter

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